Recently, Wu Yihui, a researcher at the State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, based on fiber-optic mode coupling characteristics, proposed a non-standard ultra-high sensitivity biosensor based on fiber coupler. The detection of biomarkers such as cancer is of great significance.
Acute myocardial infarction (AMI) is a common clinical acute onset, which seriously threatens people's life and health. Early diagnosis and risk stratification of AMI have important clinical significance for reducing acute mortality. Cardiac troponin I (cTnI) is a structural protein subtype present only in cardiomyocytes and is considered the "gold standard" for AMI detection due to its remarkable specificity and sensitivity. When myocardial injury occurs, cTnI is released and enters the blood circulation system for a few hours and then peaks and maintains for 6 to 8 days, but as a biomarker, the concentration of cTnI in the blood before and after the onset of AMI is extremely low, which is very important for clinical diagnosis. Demanding requirements.
Based on the research work of the pre-standard optical fiber biosensors, the research group proposed a biosensor based on the fiber coupler structure. The sensor is based on the interference effects of odd and even modes in the fiber coupler. The two coherent modes are effective. When the refractive index is equal, a turning point, that is, zero dispersion occurs, and the sensitivity theory at this time is infinity. In the experiment, the refractive index sensitivity obtained by detecting the spectral curve of the near turning point is 91777.9nm/RIU, and the detection limit of cTnI is 2fg/mL, which is the highest sensitivity obtained in the international related field, and the fiber coupler sensor has good performance. The specificity and reproducibility are of great significance for the practical application of biosensors in the later stage.
Related research results were published on Biosensors and Bioelectronics. The research work was supported by the China-Israel National International Science and Technology Cooperation Project, the National Natural Science Foundation's major scientific research instrument development project, and the National Natural Science Youth Fund.
Deployable Drums,Deployable Drum With Wheels,Portable Pre-Terminated Cable Drum,Pre-Terminated Cable Drum
ShenZhen JunJin Technology Co.,Ltd , https://www.jjtcl.com