Shanghai Xinfan Bio: New Genes in BMI-1 Related to Stem Cell Maintenance in Other Cancers |

The researchers confirmed that the gene BMI-1, which is involved in stem cell maintenance in other cancers, is an extremely important regulator of colon cancer stem cells, driving periodic self-renewal, proliferation and cell survival. This is the first step toward the clinical application of cancer stem cell biology principles to control cancer growth and promote the development of durable treatment. In a preclinical trial, the team replayed human colon cancer in mice to determine whether specific targeting of stem cells is clinically significant. First, the researchers confirmed that the gene BMI-1, which is involved in stem cell maintenance in other cancers, is an extremely important regulator of colon cancer stem cells, driving periodic self-renewal, proliferation, and cell survival. Next, the team successfully blocked BMI-1 using an existing small molecule inhibitor, thus demonstrating the clinical significance of this approach. "Inhibiting a well-established self-renewal regulatory factor is an effective way to control tumor growth," the researchers wrote. "There is strong evidence to prove that self-renewal as a therapeutically targeted biological process is clinically significant." "When we block the BMI-1 signaling pathway, stem cells are unable to self-renew," the researchers said. "This leads to long-term, irreversible damage to tumor growth. In other words, cancer is permanently terminated." The researchers said: “This study has exciting clinical potential and it has portrayed a viable approach to targeted therapy development for colon cancer patients. It is well known that approximately 65% ​​of colon cancer patients have BMI-1 biomarkers. The target, and an effective method for it, can easily transform this knowledge into the first human trial, providing more individualized cancer care."

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